Endolith’s Liz Dennett: On transforming mining through bio-intelligence
Endolith’s Liz Dennett: On transforming mining through bio-intelligence
Words Liz Dennett
May 8th 2025 / 8 min read
Endolith didn’t start in a research laboratory or dusty academic library.
It started over a pint, in a dimly lit Edinburgh pub during a late-night brainstorm that continues to shape how we talk about the company today.
During drinks with a few scientist friends, the topic of conversation turned particularly ‘science-y’. What single resource was going to be the most impactful in terms of the trajectory of humanity, someone asked.
Various offerings were made. I suggested water, only to be quickly rebuffed by my friends, given the advances in technology dedicated to producing fresh water.
Copper was another suggestion. Without it, the future of clean energy grinds to a halt. Between now and 2050, we need more copper than we’ve ever needed in the entire history of human civilization. And as it stands, there's no way to get there without being truly devastating to the environment.
A lightbulb went on in my head. “Why don't we just engineer microbes to extract more copper, more efficiently?” And someone turned to me and said, “Okay, Liz, why don’t you do that?”
Microbes are nothing new to the mining industry—they’ve been using them for years. I often refer to microbes as ‘the world’s oldest miners’. But what I’ve realised, over my career and my time as CEO of Endolith, is that microbes are just one piece of the puzzle. Building these fascinating organisms into a biological intelligence platform–a system where engineered microbes are paired with AI and real-time data to adaptively improve copper recovery has been key to our success so far, and could prove to be game-changing for how we source our critical minerals.
Here’s the journey I’ve been on so far, and what I’ve learned along the way.
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Subscribe hereBalancing natural beauty & critical resources
From a young age, I gained an appreciation for the delicate balance of preserving our natural world and meeting our society’s demand for natural resources.
I grew up in Alaska, where these two things sit shoulder to shoulder. As a child, I spent a lot of time in the great outdoors, hiking, camping, fishing, and so on. I was also surrounded by heavy industry—mining in particular. My dad was an oil and gas geologist, and I knew friends’ parents who worked in Red Dog Mine, one of the world’s largest zinc mines.
It’s easy to draw a line between these two things, and the studies and career I pursued—a nebulous intersection of technology, sustainability, and commercial impact. In short, I was fascinated by how combining technology and the natural world could help us unlock cleaner, more efficient ways of doing things.
That curiosity took me all the way to Mars—well, almost. I ended up at NASA studying astrobiology, using microbes on Earth to model life on other planets. These studies, and the interests at their heart, led me to Edinburgh, to that fateful pub meetup, and ultimately to Endolith.
Endolith: A snapshot
Year founded: 2023
Joined Founders Factory: 2024 (backed by Rio Tinto)
Employees: 18
Total raised: $5.5M
Key markets: US, Australia, South America
Starting broad, finding focus
After I finished my PhD, my fascination with bioengineering led me to join Cemvita as CTO. Cemvita is a company trying to transform heavy industry through synthetic biology. They have various groups working on different solutions, including a biomining group based in Denver. The board asked me to step in and lead this division, where we explored various microbial applications across the mining process. Crucially, I saw that we had to narrow down our focus. Microbes had applications across the board—in lithium extraction, nickel laterites, and copper. The problem is that the industry doesn’t reward future potential, so there was no point in us becoming another platform that could spin off various products.
The best advice someone gave me was: cash is king, focus is queen. So I got our team to find an urgent problem to solve now. Where could we have an immediate impact on industry and the energy transition—not in ten years, but right now? Calling back to that moment in the pub in Edinburgh, we landed on copper, namely, finding ways to use microbes to extract it far more efficiently.
So like that, we went from five products to one product, and spun out as an independent company: Endolith. And microbes are just one piece of the puzzle. We’ve also built a novel biointelligence platform—part biology, part machine learning—designed to extract more from less and adapt in real time.. For the mining industry, we’re already seeing proof, validated through testing with BHP’s Think & Act Differently (TAD) program, that Endolith’s microbes can meaningfully boost copper recovery from low-grade ores and waste, revealing new value in material previously considered uneconomic.
The challenges of scaling deep tech
Early on, I assumed that if we could make the tech work, or even build the best possible technology, then success would follow. As it turns out, this was incredibly naive. Scaling deep tech out of the lab is incredibly hard.
To succeed, market adoption has to be inevitable. To do this, your product can’t be 10% better, or 20% better: it has to be the easiest possible choice, something your customers can just plug into what they’re doing already and see huge results.
Even given this, finding a buyer in this industry is a significant obstacle. Mining is a centuries-old industry, and while we’ve seen tremendous innovation over the past few decades, this has always moved cautiously. This industry values safety almost above everything else. People can get injured if you move too quickly and something goes wrong. Anything that threatens that will see push back.
I’ve tried coming in as an outsider, thinking that you'll change them because you know better, before you’ve spent time listening or trying to understand their industry. I saw no success trying that approach. You must show you know their industry, empathise with what they value, and demonstrate a way to work forward.
Working with Rio Tinto through the Founders Factory Mining Tech Accelerator gave us tremendous insight into the dynamics of selling to the mining industry and working with a large multinational.
For one, it’s great validation for what we’re working on. It shows that industry leaders see our technology and startups like Endolith as the future. On top of this, it’s an accelerant to securing engagement with other companies. If we can show that we’re working with X of the biggest copper customers, that will help push other companies over the line.
To go back to my point earlier, the hardest thing about deep tech is generally not the science. It’s about demonstrating a fundamental paradigm shift in the future that makes your science inevitable, meaning large companies cannot ignore you.
Endolith today, and the next five years
As a CEO, I’ve had the pleasure of witnessing a number of exciting milestones. These range from the big moments—closing our $5M seed round last year—to the quiet ones, like walking into the lab and seeing our team huddled around a whiteboard, solving hard problems together.
The team I’ve helped assemble is undoubtedly our greatest asset, and has been one of the most important things I’ve had to do as CEO. In the early days, I was terrible at this: at first, I hired people who thought like me, because I thought that’s what made a good team. Turns out, I needed the opposite. Learning to lead people who challenge me has been just as humbling as any scientific breakthrough. I see a lot of scientists with this same approach—” I’m not a people person”. But neither was I, and I made it something I had to study like any other scientific feature. You truly cannot underestimate how instrumental this is to your success.
This year, our team is all-in on field validation and commercial deployment. We’re finally taking the technology out of the lab, launching our first proofs-of-concept with some of the world’s largest mining companies, and laying the groundwork for full-scale adoption.
In 3 to 5 years, every major mining company will be using some form of biological intelligence in extraction,: and if we’re successful in proving our ability to do this, Endolith will be at the forefront of this transition.
Beyond this, there’s an even bigger picture. That question we mulled over in a pub in Edinburgh—what single resource could shape the future of humanity—still drives us. What started as a wild idea over drinks has become a platform that could transform how we value, recover, and reuse Earth’s most essential materials.
Microbes don’t just belong in mining: you can apply them to any process, whether it’s recovering metals from e-waste, extracting rare earth elements from discarded batteries, or even remediating industrial wastewater where you’re trying to extract more value out of waste material. If we succeed, one day you’ll walk through a copper mine that looks more like a biotech lab. And the waste piles? They’ll be our next harvest. Endolith can be a fundamental component of the material value chain.
About Liz
Liz Dennett is CEO & Founder of Endolith, which she joined from her role as CTO at Cemvita. She earned her PhD in geomicrobiology and astrobiology from the University of Wisconsin-Madison, where she studied with NASA Astrobiology Institute to understand development of early life in ancient and extraterrestrial environments. She has previously held technical roles at AWS and Wood Mackenzie.
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